Question 1

Does the tool cover over-the-counter medications?

Accepted Answer

Yes — common OTC drugs are included: ibuprofen (avoid in 3rd trimester — risk of oligohydramnios and premature ductus arteriosus closure), paracetamol (preferred analgesic in pregnancy, but do not exceed 3 g/day), antihistamines, and antacids.

Question 2

How should I interpret the term 'limited human data'?

Accepted Answer

'Limited human data' means no well-controlled studies exist, but post-marketing reports and case series have not identified a major teratogenic signal. The drug is not contraindicated but should be used only when the expected benefit clearly outweighs the theoretical risk. Documentation of the risk-benefit discussion is recommended.

Question 3

Is it safe to take antidepressants during breastfeeding?

Accepted Answer

Most SSRIs/SNRIs (sertraline, paroxetine, fluoxetine, citalopram, venlafaxine) are considered compatible with breastfeeding, with sertraline having the lowest relative infant dose (~2% of the maternal weight-adjusted dose). Monitor the infant for sedation, poor feeding, and changes in sleep pattern in the first weeks of exposure.