Question 1

What GFR estimation method should be used with the Calvert formula?

Accepted Answer

Cockcroft-Gault is the historical standard. CKD-EPI has not been validated for carboplatin. Measured GFR (³Cr-EDTA, iohexol) is gold standard for dose-intensive regimens.

Question 2

How should I adjust carboplatin dosing for elderly patients?

Accepted Answer

Cockcroft-Gault may overestimate GFR in elderly patients. Consider measured GFR. Starting at a lower target AUC (e.g., 4–5 instead of 6) is common.

Question 3

Does the Calvert formula apply to paediatric patients?

Accepted Answer

The paediatric formula is Dose = Target AUC × (GFR + 15) × BSA/1.73. Use Schwartz formula for GFR and consult paediatric protocols.

Question 4

What is the relationship between carboplatin dose and thrombocytopenia?

Accepted Answer

Thrombocytopenia is dose-limiting. AUC 7 typically produces a platelet nadir at 2–3 weeks. The formula is designed to achieve predictable haematological toxicity.